Clinical Trial

THRIVE in Sedated Gastrointestinal Endoscopy

Completed
View on ClinicalTrials.gov →
Summary
This prospective observational study aims to evaluate the effectiveness of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) compared to standard nasal cannula (SNC) oxygen supplementation in patients undergoing elective diagnostic gastroscopy under propofol sedation. The primary outcome is the incidence of hypoxemia (SpO₂ \<93% for ≥20 seconds) during the procedure. Secondary outcomes include the need for airway intervention, Oxygen Reserve Index (ORi) values, peripheral oxygen saturation (SpO₂) levels, and hemodynamic parameters recorded throughout the procedure. Oxygen delivery method was selected by the attending anesthesia provider independent of the study team.
Trial Details
NCT Number NCT07487051
Lead Sponsor Fatih Sultan Mehmet Training and Research Hospital
Conditions Hypoxemia, Gastrointestinal Endoscopy
Enrollment 222 participants
Start Date 2025-07-01
Primary Completion 2025-10-01 (estimated)
Study Completion 2025-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-23