Clinical Trial

Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)

Study acronym: HOPE65
Not Yet Recruiting
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Summary
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments. Orthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults. The main questions this study aims to answer are: * How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older. * Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline). Participants will: * have blood pressure measured while lying down and standing * have blood pressure measured after a meal * undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status * provide information about medications and medical history * be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death
Trial Details
NCT Number NCT07485998
Lead Sponsor University Medical Centre Ljubljana
Conditions Orthostatic Hypotension, Postprandial Hypotension
Enrollment 500 participants
Start Date 2026-04
Primary Completion 2030-04 (estimated)
Study Completion 2030-06 (estimated)
Updated on ClinicalTrials.gov 2026-03-20