Multimodal Intervention for Early Chronic Kidney Disease in Young People: Dysbiosis and Inflammation (CKD)

Chronic kidney disease (CKD) is a progressive condition associated with substantial morbidity, mortality, and healthcare costs. Early detection and timely intervention are critical to modify disease trajectory, particularly in adolescents and young adults. Emerging evidence supports the role of the gut-kidney axis in CKD progression, whereby intestinal dysbiosis contributes to systemic inflammation and accumulation of microbiota-derived uremic toxins. This randomized controlled clinical trial aims to evaluate whether a multimodal intervention consisting of a controlled diet, structured exercise, and a symbiotic administered for 180 days improves uremic toxin burden, systemic inflammation, and early renal outcomes compared with standard care plus placebo.

NCT Number	NCT07483697
Lead Sponsor	Centenario Hospital Miguel Hidalgo
Conditions	Exercise, Diet Interventions, Symbiotic, CKD Stage 1, CKD Stage 3, CKD Stage 2
Enrollment	200 participants
Start Date	2026-04-25
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-11-03 (estimated)
Updated on ClinicalTrials.gov	2026-03-19