A Phase II Trial of Fetal Embolization for Vein of Galen Malformation

This is a prospective, single-arm non-randomized interventional study of fetuses to assess the efficacy and safety of fetal embolization of VOGM. Subjects will receive a one-time study intervention of fetal embolization, at or after 34 weeks of gestation. After delivery, neurological assessments will be performed every 6 months for 2 years (adjusted for gestational age). Data will be compared to historical cohorts.

NCT Number	NCT07483255
Lead Sponsor	Darren Orbach
Conditions	Vein of Galen Malformations
Enrollment	20 participants
Start Date	2026-07-20
Primary Completion	2030-12 (estimated)
Study Completion	2032-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-23