Valsalva SBP Drop and LVOT Obstruction

This study aimed to evaluate the efficacy of non-invasive dynamic blood pressure monitoring in assessing left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy. We prospectively collected SBP waveforms and LVOT gradient data from patients with obstructive and non-obstructive disease, systematically analyzed their correlation, and explored its clinical value in different clinical scenarios.

NCT Number	NCT07483125
Lead Sponsor	Shanghai Zhongshan Hospital
Conditions	HCM, oHCM, nHCM
Enrollment	800 participants
Start Date	2025-12-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-19