Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer

This multicenter prospective randomized clinical trial aims to compare the safety and oncological effectiveness of proximal gastrectomy and total gastrectomy in patients with locally advanced Siewert type II-III gastroesophageal junction cancer. Eligible patients will be randomly assigned to undergo either proximal gastrectomy or total gastrectomy using open, laparoscopic, or robotic surgical approaches according to clinical suitability. The primary outcome of the study is 3-year disease-free survival. Secondary outcomes include postoperative mortality, postoperative complications, and the number of metastatic lymph nodes retrieved. Patients will be followed for up to five years after surgery to evaluate long-term oncological outcomes.

NCT Number	NCT07482566
Lead Sponsor	Nurettin Şahin Collaborators: Ankara City Hospital Bilkent, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul University - Cerrahpasa
Conditions	Gastroesophageal Junction Cancer, Stomach Neoplasms, Esophageal Neoplasms
Enrollment	120 participants
Start Date	2026-02-01
Primary Completion	2028-02-01 (estimated)
Study Completion	2033-02-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-20