Clinical Trial

Antibiofilm Activity of Chitosan Nanoparticles Against Uropathogenic Escherichia Coli

Not Yet Recruiting
View on ClinicalTrials.gov →
Summary
1. Isolation of uropathogenic Escherichia coli (UPEC) and determination of their Antimicrobial sensitivity Patterns. 2. Evaluation of biofilm-forming capacity of UPEC isolates. 3. Assessment of the antibiofilm efficacy of chitosan nanoparticles alone and in combination with ciprofloxacin against UPEC isolates. 4. Examination of the effectiveness of chitosan nanoparticle coating in preventing biofilm formation by UPEC on urinary catheter surfaces. 5. Evaluation of the impact of chitosan nanoparticles on the expression levels of biofilm associated genes in UPEC.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-03-15.
Trial Details
NCT Number NCT07482553
Lead Sponsor Assiut University
Conditions Urinary Tract Infections (UTIs), Catheter-Associated Urinary Tract Infections (CAUTIs), Biofilm Formation by Uropathogenic Escherichia Coli (UPEC)
Enrollment 60 participants
Start Date 2026-05-01
Primary Completion 2027-05 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-03-27