Berberine Supplementation, Sprint Interval Training, and Immune Function Study

The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?

NCT Number	NCT07480018
Lead Sponsor	University of Northern Colorado
Conditions	Berberine, Sprint Training, Wellbeing, Anaerobic Power, Inflammation Biomarkers, Monocyte Function
Enrollment	40 participants
Start Date	2026-01-01
Primary Completion	2026-05-03 (estimated)
Study Completion	2026-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-05