Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy

Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life. Although pancreatic enzyme replacement therapy (PERT) is the standard treatment, some patients remain symptomatic despite apparently adequate therapy. Possible causes include suboptimal dosing or concomitant conditions such as small intestinal bacterial overgrowth (SIBO). This study aims to determine the prevalence of SIBO in symptomatic PEI patients despite adequate PERT and to identify treatable causes of persistent symptoms using non-invasive diagnostic tests, with the goal of improving nutritional status and quality of life.

NCT Number	NCT07479238
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions	SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic Surgey
Enrollment	100 participants
Start Date	2026-04-30
Primary Completion	2027-04-30 (estimated)
Study Completion	2028-04-26 (estimated)
Updated on ClinicalTrials.gov	2026-04-13