Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty

Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation. Various regional anesthesia techniques are used as part of multimodal analgesia protocols to improve postoperative pain control. Genicular nerve block has recently been introduced as a potential motor-sparing technique that may enhance postoperative analgesia when used alone or in combination with other regional blocks. The aim of this randomized controlled study is to evaluate whether the addition of ultrasound-guided genicular nerve block to femoral nerve block improves early postoperative analgesia in patients undergoing primary unilateral total knee arthroplasty under combined spinal-epidural anesthesia. A total of 80 patients aged 18-80 years scheduled for elective primary unilateral TKA will be included and randomly assigned to two groups using sealed envelopes. One group will receive femoral nerve block alone (Group F), while the other group will receive femoral nerve block combined with genicular nerve block (Group FG). Postoperative pain scores using the visual analog scale (VAS), epidural patient-controlled analgesia consumption during the first 24 hours, and the time to additional analgesic requirement will be recorded and compared between the groups.

NCT Number	NCT07478783
Lead Sponsor	Ankara City Hospital Bilkent
Conditions	Total Knee Anthroplasty
Enrollment	80 participants
Start Date	2021-11-01
Primary Completion	2021-11-01 (estimated)
Study Completion	2022-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-25