Clinical Trial

Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

Study acronym: MA-CRC-II-018
Recruiting Phase 2
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Summary
The goal of this clinical trial is to learn if SHR-1701 combine with chemoradiotherapy works to treat severe CRC. Participants will take: Induction: SHR-1701 combined with CAPOX for one cycle. Radiotherapy: Short-course radiotherapy (SCRT) (25Gy/5F). Consolidation: SHR-1701 combined with CAPOX for five cycles, after which the subjects undergo TME surgery.
Trial Details
NCT Number NCT07478731
Lead Sponsor Hong Qiu
Conditions CRC (Colorectal Cancer)
Enrollment 48 participants
Start Date 2025-12-20
Primary Completion 2027-12-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-17