Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery

A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative emotional states (anxiety, depression) in patients undergoing elective cardiac surgery.

NCT Number	NCT07476742
Lead Sponsor	Chinese PLA General Hospital Collaborators: Navy General Hospital, Beijing
Conditions	Postoperative Delirium (POD), Postoperative, Anxiety, Depression, Cardiac Surgical Procedures
Enrollment	270 participants
Start Date	2026-02-28
Primary Completion	2027-02-28 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-17