Clinical Trial

Counterpain PXM Versus Diclofenac Versus Piroxicam

Completed Phase 3
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Summary
The goal of this clinical trial is to learn if a gel containing Piroxicam plus Counterirritant (warming/cooling ingredients) is as effective and safe as two other common anti-inflammatory gels for treating acute muscle, bone, and joint pain in adults aged 18-60. The main questions it aims to answer are: Does the Piroxicam plus Counterirritant gel provide a similar level of pain relief as the standard Piroxicam-only gel and the Diclofenac gel? Is the Piroxicam plus Counterirritant gel as safe to use as the other two gels? Researchers will compare three groups of participants, each using one of the gels (Piroxicam plus Counterirritant, Piroxicam-only, or Diclofenac) to see if the combination gel works equally well. Participants will: * Be randomly assigned to use one of the three gels for approximately 6 days. * Visit the clinic three times (at the start, midpoint, and end) for pain assessments, physical exams (checking movement and muscle strength), and physiotherapy sessions. * Apply their assigned gel at home three times daily (morning, afternoon, evening) and record their gel use and pain levels in a provided diary. * Receive a rescue medication (paracetamol) to use only if their pain becomes unbearable and record when they take it.
Trial Details
NCT Number NCT07475663
Lead Sponsor Taisho Pharmaceutical Indonesia
Conditions Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee, Tennis Elbow, Runner's Knee
Enrollment 180 participants
Start Date 2025-11-04
Primary Completion 2026-02-12 (estimated)
Study Completion 2026-02-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-16