Clinical Trial

A Pilot Study on Skeletal Muscle Proteome Dynamics in Younger and Older Men Undertaking Normal Activity or Resistance Exercise Training.

Study acronym: LHMA Pilot
Completed
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Summary
The goal of this basic research study is to investigate effect of resistance exercise on the quality of muscle proteins in younger and older men. The main question\[s\] it aims to answer \[is/are\]: whether there is a difference in muscle protein quality between younger and older adults and if resistance exercise training has a beneficial impact on the quality of muscle proteins? Participants will perform five bouts of unilateral leg press exercise during a 14 day period of deuterium oxide consumption and biopsy samples will be taken from both their exercised leg and non-exercised leg before and after the intervention period to enable the measurement of muscle protein abundances and turnover rates.
Trial Details
NCT Number NCT07473297
Lead Sponsor Liverpool John Moores University
Collaborators: Biotechnology and Biological Sciences Research Council
Conditions Ageing Well
Enrollment 8 participants
Start Date 2023-03-10
Primary Completion 2023-03-12 (estimated)
Study Completion 2025-08-28 (estimated)
Updated on ClinicalTrials.gov 2026-03-16