Clinical Trial

Small Bowel Capsule Endoscopy in Lynch Syndrome

Study acronym: iCARE4Lynch
Recruiting
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Record status
This record was last updated March 16, 2026 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.
Trial Details
NCT Number NCT07472686
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Conditions MMR Mutation, Small Bowel Adenoma, Small-bowel Adenocarcinoma, Lynch Syndrome, Cancer
Enrollment 400 participants
Start Date 2025-06-16
Primary Completion 2026-06 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-16