Impact of Androgen Signaling on the Composition of the Immune Microenvironment in Glioblastomas

Glioblastoma (GBM) is the most common and most aggressive primary brain cancer in adults. GBM is more common in men than in women, with a male-to-female ratio of 1.6. Furthermore, being male is associated with a poorer prognosis. These data suggest that sex and/or sexual hormones and more specifically androgens may play a role in the initiation, the growth, and the resistance to treatments of GBM.

NCT Number	NCT07472387
Lead Sponsor	Assistance Publique - Hôpitaux de Paris
Conditions	Glioblastoma (GBM)
Enrollment	40 participants
Start Date	2026-04-01
Primary Completion	2030-04-01 (estimated)
Study Completion	2030-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-16