Sleep, Light, Circadian, Central Oxidative Stress

Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease. Potential pathways underlying the adverse cognitive function and brain health associated with irregular insufficient sleep include misalignment of sleep from the internal \~24-hour body clock and brain oxidative stress. This research will investigate these putative pathways and inform future interventions to mitigate the impact of sleep loss on cognition and brain health.

NCT Number	NCT07471126
Lead Sponsor	Beth Israel Deaconess Medical Center
Conditions	Non-visual Effects of Light, Chronic Variable Sleep Deficiency
Enrollment	40 participants
Start Date	2026-07-01
Primary Completion	2029-03-30 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-11