Skin Involvement in Dupuytren Surgical Treatment Outcome

Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult. Based on clinical experience in DD surgery and outcome, it is suspected that recurrence may be associated with such retracted skin. Possibly, this is due to presence and persistence of aligned myofibroblasts (MF), fixed to the deepest dermal layers. This interventional study aims to investigate the pathophysiological involvement of palmar skin in Dupuytren disease, and its implications for prognostics and treatment.

NCT Number	NCT07470684
Lead Sponsor	Universitaire Ziekenhuizen KU Leuven
Conditions	Dupuytren Disease
Enrollment	50 participants
Start Date	2024-12-10
Primary Completion	2027-01-01 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-10