Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.

Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets. This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function. The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.

NCT Number	NCT07470593
Lead Sponsor	University Hospital, Strasbourg, France
Conditions	Type 1 Diabetes (T1D)
Enrollment	36 participants
Start Date	2025-12-15
Primary Completion	2029-12-15 (estimated)
Study Completion	2029-12-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-17