Clinical Trial

Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery

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Record status
This record was last updated March 13, 2026 (before its estimated July 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies. This prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.
Trial Details
NCT Number NCT07469332
Lead Sponsor Ankara City Hospital Bilkent
Conditions Postoperative Recovery, PONV
Enrollment 135 participants
Start Date 2026-03-30
Primary Completion 2026-07-30 (estimated)
Study Completion 2026-07-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-13