Clinical Trial

Gingival Crevicular Fluid Biomarkers and Healing After Root Canal Treatment in Asymptomatic Apical Periodontitis

Active, Not Recruiting
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Record status
This record was last updated March 12, 2026 (before its estimated May 2026 completion). Its status may not reflect the trial's current state.
Summary
This prospective observational cohort study will evaluate whether changes in gingival crevicular fluid osteoprotegerin (OPG) , RANKL/OPG ratio ,IL10,IL8and CxCL10 after primary nonsurgical root canal treatment are associated with 12-month radiographic healing in teeth with asymptomatic apical periodontitis. Participants will undergo standardized treatment and follow-up with serial GCF sampling and standardized digital periapical radiography.
Trial Details
NCT Number NCT07468643
Lead Sponsor Faculty of Dental Medicine for Girls
Conditions Pulp and Periapical Tissue Disease
Enrollment 60 participants
Start Date 2025-05-02
Primary Completion 2026-05 (estimated)
Study Completion 2026-05 (estimated)
Updated on ClinicalTrials.gov 2026-03-12