Exercise for an Aging Liver (EXALIVER)

The goal of this clinical trial is to learn how physical exercise affects liver health in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or at-risk metabolic dysfunction-associated steatohepatitis (MASH); comparing responses between middle-aged adults (40-60 years old) and older adults (70 years and older) of any sex, as well as between participants with low-risk MASLD and high-risk MASH. The main question it aims to answer is: Could an exercise program reduce liver fat, inflammation and fibrosis, regardless of age and disease severity? Researchers will compare 4 different groups: A) older adults with at risk MASH who will exercise B) middle-aged people with at risk MASH who will exercise C) middle-aged people with low-risk MASLD who will exercise D) middle-aged people with low-risk MASLD who will not exercise, receiving usual care. Participants in the exercise groups will take part in a supervised 12-week exercise program that includes both strength and aerobic training, completed twice a week. All participants, including those receiving usual care, will have health asssessments before and after the 12-week period to measure changes in liver health.

NCT Number	NCT07467512
Lead Sponsor	Consorcio Centro de Investigación Biomédica en Red (CIBER) Collaborators: Hospital General Universitario Gregorio Marañon, Universidad de Granada, Universidad Politecnica de Madrid, Universidad Complutense de Madrid, Instituto Mixto Universitario Deporte y Salud
Conditions	MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis/NASH
Enrollment	40 participants
Start Date	2026-03
Primary Completion	2027-06 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-12