Clinical Trial

Exploratory Clinical Study of TCR-T for MAGE-A4-positive Mesenchymal Malignancies

Recruiting Phase 1
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Summary
RATIONALE: MAGE-A4 is a cancer-testis antigen widely expressed in various mesenchymal tumors but absent in normal tissues, making it an ideal immunotherapeutic target. Given the limited effectiveness of conventional therapies in advanced mesenchymal tumors, this study seeks to explore a novel treatment approach by engineering autologous T cells with a high-affinity TCR specific for MAGE-A4. PUOPOSE: This exploratory clinical study will assess safety profiles, treatment tolerance, and preliminary antitumor activity in patients with advanced mesenchymal malignancies.
Trial Details
NCT Number NCT07467122
Lead Sponsor Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions Advanced Mesenchymal Malignancies
Enrollment 15 participants
Start Date 2026-03-15
Primary Completion 2029-12-31 (estimated)
Study Completion 2031-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-12