L-serine and Strength Training in the Elderly

This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.

NCT Number	NCT07466290
Lead Sponsor	University of Vienna Collaborators: Medical University of Vienna
Conditions	Brain Health, Longevity, Cognitive Performance, Strength Training Effects, Healthy Ageing, Ageing, Cognition, Memory +1 more
Enrollment	126 participants
Start Date	2026-03
Primary Completion	2027-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2026-03-12