A First-in-Human Study of the CIPHER System During Brain Surgery for Newly Diagnosed Glioma

The goal of this clinical trial is to collect data on the use of the CIPHER System when used by a surgeon during brain tumor removal. The main questions it aims to answer are: * To evaluate the safety of the CIPHER System when used during brain tumor surgery (Primary) * To evaluate the function of the electrodes under recording and stimulating conditions during surgery (Secondary) Participants will undergo standard-of-care surgery to remove their tumor. Just before the tumor is removed, the CIPHER System will be tested on the main tumor and the surrounding margin areas. Participants will be monitored during standard hospital visits occurring during the recovery period after surgery as well as two- and six-weeks after surgery.

NCT Number	NCT07465796
Lead Sponsor	Coherence Neuro Australia Pty Limited Collaborators: Royal Melbourne Hospital, Australia
Conditions	Glioma, Tumor, Electrocorticography, Brain
Enrollment	10 participants
Start Date	2026-05-22
Primary Completion	2026-09 (estimated)
Study Completion	2026-09 (estimated)
Updated on ClinicalTrials.gov	2026-06-03