Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult

High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery. In specific groups of patients such as the obese and after upper abdominal surgery the results are contradictive. However, there is lack of evidence if HFNO in the general high-risk patient after abdominal and non-cardiac thoracic surgery can reduce the prevalence of PPC, hypoxaemia and escalation of therapy. Therefore, the investigators aim to compare the use of HFNO with conventional oxygen therapy (COT) in high-risk patients after abdominal and non-cardiac thoracic surgery regarding postoperative pulmonary complications.

NCT Number	NCT07464730
Lead Sponsor	Region Stockholm Collaborators: Karolinska Institutet
Conditions	Postoperative Pulmonary Complications (PPCs)
Enrollment	200 participants
Start Date	2026-04-20
Primary Completion	2028-03-09 (estimated)
Study Completion	2029-03-09 (estimated)
Updated on ClinicalTrials.gov	2026-05-14