Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure

Acute hypoxemic respiratory failure may progress to acute respiratory distress syndrome, a life-threatening condition that often requires mechanical ventilation. The optimal ventilation strategy in this patient population remains uncertain. The SVALBARD trial is a feasibility and pilot study designed to compare spontaneous versus controlled mechanical ventilation in patients with acute hypoxemia respiratory failure. The primary objective is to assess the feasibility of the study procedures and interventions, while also collecting descriptive data on key clinical variables to inform the design of a future randomized controlled trial.

NCT Number	NCT07463885
Lead Sponsor	Oslo University Hospital Collaborators: Rigshospitalet, Denmark, Aalborg University Hospital
Conditions	Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure
Enrollment	80 participants
Start Date	2026-09-01
Primary Completion	2027-09-01 (estimated)
Study Completion	2028-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-13