Clinical Trial

A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring

Study acronym: EC50 via TCI
Completed
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Summary
1. The combined induction of intubation with propofol and remifentanil is widely used in clinical anesthesia, primarily through a single intravenous injection. Target-controlled infusion (TCI) technology, which combines pharmacology with clinical practice, offers a more stable and precise infusion mode; 2. This project aims to explore the half-effective concentration (EC50) of propofol combined with remifentanil for inhibiting tracheal intubation stimulation through a sequential approach under the monitoring of qNOX pain index.
Protocol Amendment History 3 changes
critical Trial completed 2026-04-16
notable Primary completion moved earlier: 2026-06-30 -> 2026-04-13 2026-04-16
minor Completion moved earlier: 2026-12-31 -> 2026-04-13 2026-04-16
Trial Details
NCT Number NCT07462949
Lead Sponsor Guangzhou General Hospital of Guangzhou Military Command
Conditions Elective Surgery, Target Controlled Infusion (TCI), Noxious Stimuli, Tracheal Intubation Stimulation
Enrollment 70 participants
Start Date 2026-03-03
Primary Completion 2026-04-03 (estimated)
Study Completion 2026-04-06 (estimated)
Updated on ClinicalTrials.gov 2026-04-17