Clinical Trial

Dual-Target CAR-NK Cells for Biomarker-Selected Advanced Colorectal Cancer

Recruiting Phase 1/2
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Summary
This Phase 1/2 study evaluates the safety, tolerability, and preliminary anti-tumor activity of an allogeneic dual-target chimeric antigen receptor natural killer (CAR-NK) cell product in adults with advanced or metastatic colorectal cancer (CRC). Participants are assigned to one of three dual-target arms based on tumor antigen co-expression: (1) CEA+GUCY2C, (2) CEA+HER2, or (3) GUCY2C+HER2. Following dose escalation, the most suitable target pair (based on safety, feasibility, and early efficacy/biomarker signals) will be selected for dose expansion.
Trial Details
NCT Number NCT07462650
Lead Sponsor Beijing Biotech
Conditions Colorectal Cancer Metastatic, Adenocarcinoma of Colon
Enrollment 48 participants
Start Date 2026-02-01
Primary Completion 2027-12-21 (estimated)
Study Completion 2028-12-22 (estimated)
Updated on ClinicalTrials.gov 2026-03-10