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Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery

Study acronym: DEX-THYROID
StatusRecruiting
PhasePhase 4
Started
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Record History

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  1. Recruitment openedv4 Show 4 more changesShow less
    • Primary completion pushed from Sep 2026 to Oct 31, 2026
    • Study completion pushed from Oct 2026 to Nov 30, 2026
    • Study sites: 0 to 1
    • Start date changed from estimate of Apr 15, 2026 to Apr 13, 2026
  2. Primary completion date: Sep 2026 to Oct 31, 2026v3 Show 4 more changesShow less
    • Study completion date: Oct 2026 to Nov 30, 2026
    • Start date: Mar 2026 to Apr 15, 2026
    • Secondary endpoints: 8 to 9
    • Study description shortened, about 10 words
  3. Re-verified, no change to tracked fieldsv2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Thyroid surgery requires smooth emergence from anesthesia to minimize coughing, hemodynamic fluctuations, and agitation during extubation, which may contribute to postoperative complications such as bleeding or cervical hematoma. Dexmedetomidine, a selective α2-adrenergic receptor agonist, has sedative, analgesic-sparing, and sympatholytic properties that may improve anesthetic stability and recovery quality. This randomized controlled trial aims to evaluate the effectiveness of a continuous perioperative dexmedetomidine regimen initiated at induction of anesthesia and maintained during thyroid surgery. The study will compare dexmedetomidine combined with standard balanced anesthesia versus standard anesthesia alone in terms of anesthetic requirements and emergence quality. The primary hypothesis is that perioperative dexmedetomidine administration reduces anesthetic and opioid requirements and improves emergence quality by decreasing coughing during extubation and hemodynamic responses.
Trial Details
NCT Number NCT07462195
Lead Sponsor Bach Mai Hospital
Collaborators: Hanoi Medical University
Conditions
(from sponsor)		 Thyroid Diseases
Related terms Emergence Delirium, Postoperative Nausea and Vomiting, Thyroid Diseases
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov