Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice

POWER project is a randomized, controlled, non-profit study with the primary objective of testing the effectiveness of non-pharmacological interventions-such as physical activity, cognitive training, and dietary supplementation-in reducing depressive symptoms and preventing or delaying cognitive impairments that frequently co-occur in individuals with Major Depressive Disorder (MDD).

NCT Number	NCT07462013
Lead Sponsor	National Science and Technology Council, Taiwan Collaborators: IRCCS Centro San Giovanni di Dio Fatebenefratelli, University College Cork
Conditions	Major Depressive Disorder (MDD)
Enrollment	120 participants
Start Date	2025-10-01
Primary Completion	2028-06 (estimated)
Study Completion	2028-09 (estimated)
Updated on ClinicalTrials.gov	2026-06-17