Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract

This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.

NCT Number	NCT07462000
Lead Sponsor	Military Institute od Medicine National Research Institute
Conditions	Primary Open-Angle Glaucoma (POAG), Cataract
Enrollment	40 participants
Start Date	2026-01-21
Primary Completion	2027-01-21 (estimated)
Study Completion	2027-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-10