Clinical Trial

Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer

Study acronym: COPS
Recruiting
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Summary
The goal of this observational study is to compare two commonly used vaginal progesterone formulations - soft capsules versus pessaries - in women undergoing frozen embryo transfer (FET). The main question it aims to answer is: \- Do soft vaginal progesterone capsules provide similar or better patient satisfaction, convenience, and tolerability compared with vaginal progesterone pessaries during preparation for frozen embryo transfer? Participants undergoing FET who are prescribed vaginal progesterone as part of their endometrial preparation and luteal phase support will use one of the two formulations and complete patient-reported assessments regarding satisfaction, convenience, and tolerability. The study will also measure serum progesterone levels on the day of embryo transfer and evaluate pregnancy outcomes, including clinical pregnancy and live birth rates.
Trial Details
NCT Number NCT07461909
Lead Sponsor Instituto Valenciano de Infertilidade de Lisboa
Collaborators: Gedeon Richter Ltd.
Conditions Frozen Embryo Transfer (FET), Infertility, Artificial Cycle, Natural Cycle
Enrollment 400 participants
Start Date 2024-11-08
Primary Completion 2026-08 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-03-10