NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks

This is a randomized (1:1), placebo-controlled clinical trial that will examine the feasibility and effectiveness of a 2-day application of the NeuroCuple device for pain relief and reduction of opioid use following wisdom teeth extraction. The primary objectives are to determine whether the active NeuroCuple reduces postoperative pain and decreases opioid consumption compared to a sham (placebo) device. A total of 120 participants will be enrolled over a 1-year period and randomized to receive either the active device or an identical-appearing placebo device without the captor array layer.

NCT Number	NCT07461506
Lead Sponsor	nCap Medical Collaborators: University of Pittsburgh
Conditions	Wisdom Teeth, Wisdom Teeth Extraction or Jaw Implant
Enrollment	120 participants
Start Date	2026-06-30
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-31