Effect of Topical Insulin on Healing Rate of Pemphigus Lesions

This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to receive long-acting insulin (insulin glargine), short-acting insulin (regular insulin), or normal saline control. Treatments were applied topically twice daily for 14 days or until complete healing.

NCT Number	NCT07461103
Lead Sponsor	Alexandria University
Conditions	Pemphigus Vulgaris, Skin Erosion, Autoimmune Blistering Disease
Enrollment	20 participants
Start Date	2024-06-22
Primary Completion	2025-08-10 (estimated)
Study Completion	2025-08-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-10