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A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder

Study acronym: ONE-D BPD
StatusRecruiting
PhasePhase 1/2
Started2026-06-10
View on ClinicalTrials.gov ↗

Amendment history

2026-08-03
minor
Study Status v3
Start dateestimated 2026-06-09→confirmed 2026-06-10
2026-06-02
notable
Study Status, Contacts/Locations v2
Recruitment opened
Start date2026-05→2026-06-09
Study sitesdetails revised at 1 of 1 site
2026-04-23
minor
Study Status v1
Start date2026-03→2026-05
2026-03-04
minor
Original filing
53 trials monitored
See 1 trial at risk
This study tests a new treatment for people with borderline personality disorder (BPD). The treatment combines a medication called D-cycloserine with one day of transcranial magnetic stimulation (TMS). The main questions it aims to answer are: * How many participants complete the treatment? * How do participants feel about the treatment? * Does the treatment have neurophysiological changes on participants? * Does the treatment improve BPD symptoms? * Do the benefits last over time? Participants will be asked to: * Come to the clinic for interviews and testing * Complete weekly questionnaires for 4 weeks before the treatment day * Take D-cycloserine the night before treatment * Attend one treatment day at the clinic. On that day, they may receive up to 20 short TMS sessions (each lasting 3 minutes and separated by 30 minutes). This visit may last up to 12 hours. * Complete weekly questionnaires for 6 weeks after the treatment day.
Trial Details
NCT Number NCT07460947
Lead Sponsor Mclean Hospital
Conditions Borderline Personality Disorder (BPD)
Enrollment 20 participants
Start Date 2026-06-10
Primary Completion 2027-06 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-08-05