This study evaluated a nurse-led, culturally adapted training program in palliative and end-of-life care (N-PELTP) for oncology nurses in Oman. Nurses in the intervention group received the structured training program, while a comparison group continued usual practice during the same period. Outcomes were assessed using questionnaires completed before and after the intervention to measure palliative care knowledge, attitudes toward caring for dying patients, self-reported palliative care practices, and communication-related outcomes. The goal of the study was to determine whether a culturally adapted educational program can improve oncology nurses' readiness to deliver palliative and end-of-life care.