Eccentric Versus Concentric Quadriceps Exercises in Knee Osteoarthritis

This study aims to compare the effectiveness of eccentric and concentric quadriceps femoris strengthening exercises in patients with knee osteoarthritis. Knee osteoarthritis is a common musculoskeletal condition that causes pain, reduced joint movement, muscle weakness, and functional limitations. Participants will be assigned to perform either eccentric or concentric unilateral open kinetic chain quadriceps exercises using isotonic loading based on a 10-repetition maximum (10-RM). The exercise program will be conducted three times per week for six weeks. The primary objective is to evaluate differences in quadriceps muscle strength between the two exercise approaches. Secondary outcomes include changes in knee range of motion and functional capacity measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The results of this study are expected to provide evidence to guide exercise prescription in rehabilitation programs for patients with knee osteoarthritis.

NCT Number	NCT07460466
Lead Sponsor	Indonesia University
Conditions	Knee Osteoarthritis
Enrollment	24 participants
Start Date	2024-07-15
Primary Completion	2025-06-13 (estimated)
Study Completion	2025-11-21 (estimated)
Updated on ClinicalTrials.gov	2026-03-11