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SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier

Study acronym: SPARC
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Start date pushed from Sep 1, 2026 to Sep 8, 2026 Eligibility criteria expanded, about 22 words · Site contacts updated at 1 of 2 sites · Publications: details revised at 16 of 16 entries Show 3 more changesShow less
    • Eligibility criteria expanded, about 22 words
    • Site contacts updated at 1 of 2 sites
    • Publications: details revised at 16 of 16 entries
  2. Recruitment opened Start date changed from estimate of Jun 2026 to Sep 1, 2026 · Site details revised at 2 of 2 sitesv3 Show 2 more changesShow less
    • Start date changed from estimate of Jun 2026 to Sep 1, 2026
    • Site details revised at 2 of 2 sites
  3. Phase changed: not applicable → not specified Start date: Mar 2026 to Jun 2026 · Primary and study completion pushed from Mar 2028 to Jun 2028 · Trial arms changed: 1 → 3 · 1 morev2 Show 4 more changesShow less
    • Start date: Mar 2026 to Jun 2026
    • Primary and study completion pushed from Mar 2028 to Jun 2028
    • Trial arms changed: 1 → 3
    • Study sites: 1 to 2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
University of Utah
302 trials monitored
See 17 trials at risk
Lung Cancer
4,057 trials monitored
See 217 trials at risk
The purpose of this study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses lung cancer. Using retrospective platelet transcriptomic data from 522 patients with non-small cell lung cancer (NSCLC, the most common type of lung cancer), an approach that appears to accurately classify lung cancer has been developed. The study will build upon these retrospective analyses to prospectively recruit patients with newly diagnosed lung cancer, obtain platelet RNA samples from whole blood, and perform validation analyses. This research will also test whether this approach accurately distinguishes benign from malignant lung nodules.
Trial Details
NCT Number NCT07460440
Lead Sponsor University of Utah
Collaborators: United States Department of Defense
Conditions Lung Cancer, Lung Nodule
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov