Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes

A single-center, randomized, controlled, open-label, crossover study in currently smoking adult participants to investigate the nicotine pharmacokinetics and pharmacodynamics of Tobacco Heating System (THS) with LEVIA, a tobacco-free nicotine-containing consumable, compared to THS with TEREA, a tobacco-containing consumable, and cigarettes. The study will use a 2-period, 2-sequence design for the ad libitum use days, and a 3-period, 6-sequence Williams design for the single-use days. Across the ad libitum use and single-use period, this is a design with 5 periods and 12 sequences.

NCT Number	NCT07459712
Lead Sponsor	Philip Morris Products S.A.
Conditions	Nicotine
Enrollment	24 participants
Start Date	2026-02-01
Primary Completion	2026-02-09 (estimated)
Study Completion	2026-04-14 (estimated)
Updated on ClinicalTrials.gov	2026-05-05