International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes

Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies. IMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.

NCT Number	NCT07458867
Lead Sponsor	European Society for Trauma and Emergency Surgery Collaborators: Association of Surgeons of Great Britain and Ireland, European Society of Coloproctology, American Society of Colon and Rectal Surgeons, University of Pennsylvania
Conditions	Large Bowel Obstruction
Enrollment	500 participants
Start Date	2026-07-01
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-07-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-09