Clinical Trial

Influence of Hyaluronic Acid in the Healing of Palatal Donor Sites During Free Gingival Graft Procedures

Study acronym: HA Palate
Completed
View on ClinicalTrials.gov →
Summary
The goal of this study is to evaluate the use of a gel containing cross-linked hyaluronic acid (xHyA) at the palatal donor site following soft tissue harvesting procedures. The main questions it aims to answer are: 1) Does the use of xHyA improve post-operative patient morbidity?; 2) Does the use of xHyA improve palatal donor site healing? Researchers will compare xHyA topically applied at the palatal donor site to a negative control to see if xHyA works to minimize participants' morbidity and improve clinical healing. Participants will be equally distributed into two groups, half of them receiving xHyA. Participants will fill a visual analogue scale for subjective analyses during the first 2 post-operative weeks and will visit the dental clinic at 3, 7, 14 and 60 post-operative days for checkups and clinical examinations.
Trial Details
NCT Number NCT07458685
Lead Sponsor University of Milan
Collaborators: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions Palatal Donor Site Wound Healing, Palatal Wound
Enrollment 20 participants
Start Date 2022-09-05
Primary Completion 2025-07-24 (estimated)
Study Completion 2025-10-02 (estimated)
Updated on ClinicalTrials.gov 2026-03-09