Clinical Trial

Domestic Environmental Exposure and Progression of ILD: An Exploratory Case-Control Study

Study acronym: EXPODOM-PID
Recruiting
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Summary
The project titled "Domestic Environmental Exposure and Progression of Progressive or Stable Fibrosing Interstitial Lung Diseases: An Exploratory Case-Control Study" is a Category 3 study involving 60 patients with progressive or stable fibrosing interstitial lung diseases (ILDs). These patients are matched based on the same ILD subtype and their use or non-use of antifibrotic medication. The study aims to thoroughly describe the domestic environment of these patients and investigate the associations between the progression of pulmonary fibrosis and: i) The presence of pollutants and risk factors in the home, including concentrations of nitrogen dioxide, volatile organic compounds, aldehydes, fine particles, mold, dust mite allergens, building defects, and lifestyle habits that increase pollutant exposure. ii) The ambient air quality at the patients' addresses. Occupational exposures will also be considered in the analysis. This project is designed to enhance our understanding of how an unfavorable domestic environment impacts the progression of pulmonary fibrosis and to evaluate the effects of the CMEI (Comprehensive Environmental and Indoor Audit) on patients' ability to manage identified risk factors within their homes, their respiratory health, and their medical diagnosis. The CMEI audit is a preventive measure that could serve as a significant intervention to alter patient behavior, reduce exposure, and improve health outcomes. This project is sponsored by the Environmental Health Laboratories Department, in collaboration with Unit 1018 of the Research Center in Epidemiology and Population Health (CESP), and two investigative centers: Tenon Hospital and Paris Saint-Joseph Hospital.
Trial Details
NCT Number NCT07457502
Lead Sponsor Ville de Paris
Collaborators: Institut National de la Santé Et de la Recherche Médicale, France, Tenon Hospital, Paris, Fondation Hôpital Saint-Joseph
Conditions Assess PID Diagnosis Revision After CMEI Audit, Assess CMEI Recommendations' Impact on Respiratory Health, ILD Progression and Exposure to Indoor Environnemental Risk, ILD Progression and Exposure to Outdoor Polluants
Enrollment 100 participants
Start Date 2023-04-26
Primary Completion 2026-10-26 (estimated)
Study Completion 2026-10-26 (estimated)
Updated on ClinicalTrials.gov 2026-03-09