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Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia

Study acronym: HEART_REMOD_AD
StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Recruitment opened
    • Start date changed from estimate of May 1, 2026 to Jun 1, 2026
    • Site details revised
    v3
  2. Secondary endpoints revised (4)v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI/D (above Th6) who have AD and 24 individuals with low-level SCI/D (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling. All 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI/D population.
Trial Details
NCT Number NCT07456722
Lead Sponsor Swiss Paraplegic Research, Nottwil
Conditions
(from sponsor)		 Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D), Cardiac Remodeling
Related terms Autonomic Dysreflexia, Disease, Spinal Cord Injuries
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov