Autoimmune Neurological Diseases and Those Secondary to Immunotherapy: Study of Immunological Mechanisms and Research Into Targets of Immune Attack

The pathophysiology of neurological toxicities secondary to immune checkpoint inhibitors (ICIs) is unknown. Various mechanisms have been proposed: activation of cytotoxic CD8 T cells, autoantibodies via activation of B cells and CD4 cells, non-specific inflammation through the production of pro-inflammatory cytokines, and complement activation. The aim of this research is to characterise the pathophysiological mechanisms of neurotoxicities in cancer patients treated with ICIs.

NCT Number	NCT07456358
Lead Sponsor	Assistance Publique - Hôpitaux de Paris
Conditions	Neurological Diseases, Auto Immune Disease
Enrollment	160 participants
Start Date	2026-04-09
Primary Completion	2030-12-09 (estimated)
Study Completion	2030-12-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-07