Effectiveness and Cost-effectiveness of VTE Prevention Strategies in Gynecological Surgery

Venous thromboembolism (VTE) is a highly preventable but potentially fatal complication following gynecological surgery. The Caprini risk assessment model is widely used, but real-world evidence evaluating the net clinical benefit and cost-effectiveness of different prophylaxis strategies (mechanical vs. pharmacological) in gynecological patients with Caprini score $\\ge$ 2 is still lacking. This study aims to evaluate the relative effectiveness of basic, mechanical, and pharmacological VTE prophylaxis strategies using a retrospective 1:3 matched nested case-control design. Furthermore, a decision tree model will be constructed to evaluate the incremental cost-effectiveness ratio (ICER) of these strategies to provide health economic evidence for optimizing VTE management pathways in gynecology

NCT Number	NCT07455253
Lead Sponsor	Affiliated Hospital of Nantong University Collaborators: Nantong No. 1 People's Hospital, The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Conditions	Venous Thromboembolism, Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Gynecological Surgery
Enrollment	234 participants
Start Date	2025-11-10
Primary Completion	2026-05 (estimated)
Study Completion	2026-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-06