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Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults

Study acronym: RtM
StatusRecruiting
PhaseNot applicable
Started2025-09-22
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 6, 2026 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years.
Trial Details
NCT Number NCT07454616
Lead Sponsor National University of Singapore
Collaborators: Danone Global Research & Innovation Center
Conditions Pre-Frailty, Aging
Enrollment 40 participants
Start Date 2025-09-22
Primary Completion 2026-04-30 (estimated)
Study Completion 2026-05-08 (estimated)
Updated on ClinicalTrials.gov 2026-03-06