Clinical Trial

Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults

Study acronym: RtM

Recruiting

Record status

This record was last updated March 6, 2026 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.

Summary

Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years.

Trial Details

NCT Number	NCT07454616
Lead Sponsor	National University of Singapore Collaborators: Danone Global Research & Innovation Center
Conditions	Pre-Frailty, Aging
Enrollment	40 participants
Start Date	2025-09-22
Primary Completion	2026-04-30 (estimated)
Study Completion	2026-05-08 (estimated)
Updated on ClinicalTrials.gov	2026-03-06