Examine Impact of Topical Application of Active Versus Placebo on the Skin Microbiome in Sensitive Skin.

The purpose of this study is to build insights to understand how the placebo and active impacts the skin microbiome in women with high skin sensitivity (SS10 \> 13) and sun exposure. Microbiome samples will be taken at baseline after 2 weeks of using the placebo (base without active) as a run-in period followed by the usage of placebo for an additional 4 weeks. The participants will then start the usage of active formula for an additional 8 weeks with microbiome samples collected at the 10-week and 14-week. This will allow us to observe how the microbiome changes over time after the product usage of both placebo and active formulations relative to the pre-regimen condition. In addition, headshot photos will be taken using the Haut AI application at each time point concurrent to the microbiome sample collection to examine changes in skin appearances after the regimen.

NCT Number	NCT07454525
Lead Sponsor	AB Biotics, SA Collaborators: Hellobiome, Kaneka Americas Holding Inc.
Conditions	Skin, Skin Microbiome, Skin Microbiota, Skin Ageing
Enrollment	45 participants
Start Date	2026-02
Primary Completion	2026-04 (estimated)
Study Completion	2026-06 (estimated)
Updated on ClinicalTrials.gov	2026-03-06