Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction

Dry eye disease (DED) is a common chronic condition characterized by ocular surface discomfort and tear film instability. Evaporative DED associated with meibomian gland dysfunction (MGD) is a frequent phenotype and is often driven by inflammatory mechanisms. This randomized, double-blind, placebo-controlled trial evaluates whether an oral microbiome-focused food supplement improves dry eye symptoms and objective clinical signs compared with placebo over 8 weeks in adults with moderate evaporative DED due to MGD.

NCT Number	NCT07453212
Lead Sponsor	Varol TUNALI Collaborators: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization, Istanbul Medipol University Hospital, İstinye University
Conditions	Dry Eye, Evaporative Dry Eye Disease, Meibomian Gland Dysfunction (Disorder)
Enrollment	130 participants
Start Date	2026-03-01
Primary Completion	2026-09-30 (estimated)
Study Completion	2026-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-28