Diabetes In Asians at Risk in Youth

This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.

NCT Number	NCT07452159
Lead Sponsor	Singapore General Hospital Collaborators: SingHealth Duke-NUS Academic Medical Centre, Duke-NUS Centre of Quantitative Medicine, Data Science and Artificial intelligence Laboratory, SGH, Translational Research and Innovation Lab, SingHealth
Conditions	Young Onset Asian Diabetes (Under 40 Years)
Enrollment	3,000 participants
Start Date	2026-03-18
Primary Completion	2029-01-02 (estimated)
Study Completion	2029-01-02 (estimated)
Updated on ClinicalTrials.gov	2026-03-05